His departure, which follows allegations of sexual misconduct, leaves another vacancy in Uber's finance department as the ride-hailing company races toward an initial public offering targeted for the first half of next year.
Poetzscher, a former Goldman Sachs Group Inc. executive, had been accused of misconduct at the San Francisco-based company and was previously disciplined, the Wall Street Journal reported last month. He told the newspaper he had committed an error in judgment and expressed regret.
The Journal reported his resignation earlier Monday.
Nelson Chai, the recently appointed chief financial officer, will immediately take over Poetzscher's duties while the company searches for a replacement, said a spokesman: "We thank Cam for his four and half years of service to Uber."
Poetzscher played a key role in negotiating this year's $9.3 billion deal with SoftBank Group Corp. Uber hired Chai, a former Merrill Lynch executive, in August to drive preparations for an IPO next year. Turnover has been high in the finance group, which leaves Chai with a staffing challenge.
